The Role of the Innate Immune System in Oncolytic Virotherapy
Joint Authors
Phan, Tuan Anh
Tian, Jianjun Paul
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-12
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The complexity of the immune responses is a major challenge in current virotherapy.
This study incorporates the innate immune response into our basic model for virotherapy and investigates how the innate immunity affects the outcome of virotherapy.
The viral therapeutic dynamics is largely determined by the viral burst size, relative innate immune killing rate, and relative innate immunity decay rate.
The innate immunity may complicate virotherapy in the way of creating more equilibria when the viral burst size is not too big, while the dynamics is similar to the system without innate immunity when the viral burst size is big.
American Psychological Association (APA)
Phan, Tuan Anh& Tian, Jianjun Paul. 2017. The Role of the Innate Immune System in Oncolytic Virotherapy. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1142254
Modern Language Association (MLA)
Phan, Tuan Anh& Tian, Jianjun Paul. The Role of the Innate Immune System in Oncolytic Virotherapy. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1142254
American Medical Association (AMA)
Phan, Tuan Anh& Tian, Jianjun Paul. The Role of the Innate Immune System in Oncolytic Virotherapy. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1142254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142254