Optimally Repeatable Kinetic Model Variant for Myocardial Blood Flow Measurements with 82Rb PET
Joint Authors
Ocneanu, Adrian F.
deKemp, Robert A.
Renaud, Jennifer M.
Adler, Andy
Beanlands, Rob S. B.
Klein, Ran
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
Myocardial blood flow (MBF) quantification with R b 82 positron emission tomography (PET) is gaining clinical adoption, but improvements in precision are desired.
This study aims to identify analysis variants producing the most repeatable MBF measures.
Methods.
12 volunteers underwent same-day test-retest rest and dipyridamole stress imaging with dynamic R b 82 PET, from which MBF was quantified using 1-tissue-compartment kinetic model variants: ( 1 ) blood-pool versus uptake region sampled input function (Blood/Uptake-ROI), ( 2 ) dual spillover correction (SOC-On/Off), ( 3 ) right blood correction (RBC-On/Off), ( 4 ) arterial blood transit delay (Delay-On/Off), and ( 5 ) distribution volume (DV) constraint (Global/Regional-DV).
Repeatability of MBF, stress/rest myocardial flow reserve (MFR), and stress/rest MBF difference (ΔMBF) was assessed using nonparametric reproducibility coefficients ( R P C n p = 1.45 × interquartile range).
Results.
MBF using SOC-On, RVBC-Off, Blood-ROI, Global-DV, and Delay-Off was most repeatable for combined rest and stress: R P C n p = 0.21 mL/min/g (15.8%).
Corresponding MFR and ΔMBF R P C n p were 0.42 (20.2%) and 0.24 mL/min/g (23.5%).
MBF repeatability improved with SOC-On at stress ( p < 0.001 ) and tended to improve with RBC-Off at both rest and stress ( p < 0.08 ).
DV and ROI did not significantly influence repeatability.
The Delay-On model was overdetermined and did not reliably converge.
Conclusion.
MBF and MFR test-retest repeatability were the best with dual spillover correction, left atrium blood input function, and global DV.
American Psychological Association (APA)
Ocneanu, Adrian F.& deKemp, Robert A.& Renaud, Jennifer M.& Adler, Andy& Beanlands, Rob S. B.& Klein, Ran. 2017. Optimally Repeatable Kinetic Model Variant for Myocardial Blood Flow Measurements with 82Rb PET. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1142261
Modern Language Association (MLA)
Ocneanu, Adrian F.…[et al.]. Optimally Repeatable Kinetic Model Variant for Myocardial Blood Flow Measurements with 82Rb PET. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1142261
American Medical Association (AMA)
Ocneanu, Adrian F.& deKemp, Robert A.& Renaud, Jennifer M.& Adler, Andy& Beanlands, Rob S. B.& Klein, Ran. Optimally Repeatable Kinetic Model Variant for Myocardial Blood Flow Measurements with 82Rb PET. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1142261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142261