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Mathematical Modeling of Biofilm Structures Using COMSTAT Data
Joint Authors
Verotta, Davide
Haagensen, Janus
Spormann, Alfred M.
Yang, Katherine
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mathematical modeling holds great potential for quantitatively describing biofilm growth in presence or absence of chemical agents used to limit or promote biofilm growth.
In this paper, we describe a general mathematical/statistical framework that allows for the characterization of complex data in terms of few parameters and the capability to (i) compare different experiments and exposures to different agents, (ii) test different hypotheses regarding biofilm growth and interaction with different agents, and (iii) simulate arbitrary administrations of agents.
The mathematical framework is divided to submodels characterizing biofilm, including new models characterizing live biofilm growth and dead cell accumulation; the interaction with agents inhibiting or stimulating growth; the kinetics of the agents.
The statistical framework can take into account measurement and interexperiment variation.
We demonstrate the application of (some of) the models using confocal microscopy data obtained using the computer program COMSTAT.
American Psychological Association (APA)
Verotta, Davide& Haagensen, Janus& Spormann, Alfred M.& Yang, Katherine. 2017. Mathematical Modeling of Biofilm Structures Using COMSTAT Data. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1142280
Modern Language Association (MLA)
Verotta, Davide…[et al.]. Mathematical Modeling of Biofilm Structures Using COMSTAT Data. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1142280
American Medical Association (AMA)
Verotta, Davide& Haagensen, Janus& Spormann, Alfred M.& Yang, Katherine. Mathematical Modeling of Biofilm Structures Using COMSTAT Data. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1142280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142280