Inference of Gene Regulatory Networks Using Bayesian Nonparametric Regression and Topology Information
Joint Authors
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gene regulatory networks (GRNs) play an important role in cellular systems and are important for understanding biological processes.
Many algorithms have been developed to infer the GRNs.
However, most algorithms only pay attention to the gene expression data but do not consider the topology information in their inference process, while incorporating this information can partially compensate for the lack of reliable expression data.
Here we develop a Bayesian group lasso with spike and slab priors to perform gene selection and estimation for nonparametric models.
B-spline basis functions are used to capture the nonlinear relationships flexibly and penalties are used to avoid overfitting.
Further, we incorporate the topology information into the Bayesian method as a prior.
We present the application of our method on DREAM3 and DREAM4 datasets and two real biological datasets.
The results show that our method performs better than existing methods and the topology information prior can improve the result.
American Psychological Association (APA)
Fan, Yue& Wang, Xiao& Peng, Qinke. 2017. Inference of Gene Regulatory Networks Using Bayesian Nonparametric Regression and Topology Information. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1142357
Modern Language Association (MLA)
Fan, Yue…[et al.]. Inference of Gene Regulatory Networks Using Bayesian Nonparametric Regression and Topology Information. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1142357
American Medical Association (AMA)
Fan, Yue& Wang, Xiao& Peng, Qinke. Inference of Gene Regulatory Networks Using Bayesian Nonparametric Regression and Topology Information. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1142357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142357