Biomarker MicroRNAs for Diagnosis of Oral Squamous Cell Carcinoma Identified Based on Gene Expression Data and MicroRNA-mRNA Network Analysis
Joint Authors
Zhang, Hui
Li, Tangxin
Zheng, Linqing
Huang, Xiangya
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Oral squamous cell carcinoma is one of the most malignant tumors with high mortality rate worldwide.
Biomarker discovery is critical for early diagnosis and precision treatment of this disease.
MicroRNAs are small noncoding RNA molecules which often regulate essential biological processes and are good candidates for biomarkers.
By integrative analysis of both the cancer-associated gene expression data and microRNA-mRNA network, miR-148b-3p, miR-629-3p, miR-27a-3p, and miR-142-3p were screened as novel diagnostic biomarkers for oral squamous cell carcinoma based on their unique regulatory abilities in the network structure of the conditional microRNA-mRNA network and their important functions.
These findings were confirmed by literature verification and functional enrichment analysis.
Future experimental validation is expected for the further investigation of their molecular mechanisms.
American Psychological Association (APA)
Zhang, Hui& Li, Tangxin& Zheng, Linqing& Huang, Xiangya. 2017. Biomarker MicroRNAs for Diagnosis of Oral Squamous Cell Carcinoma Identified Based on Gene Expression Data and MicroRNA-mRNA Network Analysis. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1142429
Modern Language Association (MLA)
Zhang, Hui…[et al.]. Biomarker MicroRNAs for Diagnosis of Oral Squamous Cell Carcinoma Identified Based on Gene Expression Data and MicroRNA-mRNA Network Analysis. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1142429
American Medical Association (AMA)
Zhang, Hui& Li, Tangxin& Zheng, Linqing& Huang, Xiangya. Biomarker MicroRNAs for Diagnosis of Oral Squamous Cell Carcinoma Identified Based on Gene Expression Data and MicroRNA-mRNA Network Analysis. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1142429
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142429