Osteosarcomatous Transformation in the Setting of Mazabraud’s Syndrome: A Case Report and Review of the Literature
Joint Authors
Multani, Iqbal
Parasu, Naveen
Popovic, Snezana
Ghert, Michelle
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Mazabraud’s Syndrome is a rare condition that is defined by the presence of fibrous dysplasia lesions in the bone and intramuscular myxomas in the soft tissue.
Malignant transformation, in the setting of Mazabraud’s Syndrome, of the fibrous dysplasia lesions into a sarcomatous neoplasm occurs in less than 1% of cases—with only six previously reported cases.
Case Presentation.
Here, we present a 62-year-old Caucasian female who developed an osteosarcoma in a fibrous dysplasia lesion of the proximal femur in the background of Mazabraud’s Syndrome.
The patient was treated with wide excision and endoprosthetic reconstruction.
She declined adjuvant chemotherapy.
She is alive without evidence of disease one-year postoperatively.
Conclusion.
Patients with Mazabraud’s Syndrome remain at low risk for malignant transformation.
However, close monitoring of asymptomatic patients with this condition for radiographic changes in their lesions and/or clinical symptoms is recommended.
American Psychological Association (APA)
Multani, Iqbal& Popovic, Snezana& Parasu, Naveen& Ghert, Michelle. 2019. Osteosarcomatous Transformation in the Setting of Mazabraud’s Syndrome: A Case Report and Review of the Literature. Case Reports in Orthopedics،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1142527
Modern Language Association (MLA)
Multani, Iqbal…[et al.]. Osteosarcomatous Transformation in the Setting of Mazabraud’s Syndrome: A Case Report and Review of the Literature. Case Reports in Orthopedics No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1142527
American Medical Association (AMA)
Multani, Iqbal& Popovic, Snezana& Parasu, Naveen& Ghert, Michelle. Osteosarcomatous Transformation in the Setting of Mazabraud’s Syndrome: A Case Report and Review of the Literature. Case Reports in Orthopedics. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1142527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142527