Recurrent Hematomas following a Revision Total Hip Arthroplasty in Acquired Coagulation Factor XIII Deficiency

Abstract EN

Coagulation factor XIII (FXIII) is the final enzyme in the coagulation cascade and plays an important role in catalyzing the intermolecular cross-linking of fibrin polymers.

FXIII deficiency is a rare disorder that presents with recurrent soft tissue bleeding.

In this case report, we describe a patient with recurrent hematomas, following a revision total hip arthroplasty (THA).

A 50-year-old female patient with no past history of bleeding and with a normal perioperative coagulation profile presented with recurrent hip joint hematomas.

Her plasma FXIII activity showed a slight decrease (69%).

Therefore, the patient was diagnosed with an acquired deficiency and was administered FXIII to correct it.

The bleeding did not recur once the FXIII activity had returned to a normal level (76%).

At 2 months after the second evacuation procedure, the patient was discharged from the hospital in an ambulatory state.

There has been no recurrence of a hematoma since.

We managed a rare case of acquired FXIII deficiency, which highlighted that a patient can present with an acquired bleeding disorder despite having a normal coagulation profile.

An acquired FXIII deficiency should be suspected in patients with inexplicable, sudden-onset bleeding, as early diagnosis and treatment are important to prevent life-threatening complications.