A Case Series of Bowen’s Disease Treated with the Combination of Cryosurgery and Ingenol Mebutate and Followed Up with Optical Coherence Tomography
Joint Authors
Tsironi, Theodora
Spyridonos, Panagiota
Bassukas, Ioannis D.
Gaitanis, Georgios
Source
Case Reports in Dermatological Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-16
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Bowen’s disease (BD) is a relatively rare in situ squamous cell carcinoma (SCC) with a limited potential of becoming invasive.
Ingenol mebutate (IM) was relatively successful for the treatment of BD lesions in small case series.
Optical coherence tomography (OCT) is a promising method for the diagnosis of cutaneous keratinocytic carcinomas, including BD.
Herein we report the treatment of BD with the combination of cryosurgery and IM and the application of OCT imagining in treatment monitoring.
Patients treated within a period of 12 months are retrospectively compiled.
Treatment consisted of a mild cryosurgery session (liquid N2, open spray, and 2 freeze-thaw cycles of 15 sec each) of a field including the BD lesion and a 0.5cm rim and IM application for 4 consecutive days starting at the cryosurgery day.
Four patients (3 females; average age: 76.5 years) with 4 lesions (20-70mm maximal diameter; average 36.2mm) were included.
Healing was excellent and no relapse was observed at 12 months’ follow-up.
Baseline OCT revealed a disarranged, thickened epidermis, while a normally layered epidermis overlying a hyperreflective dermis was present after treatment.
Conclusively, the combination of cryosurgery followed by IM is a feasible, effective treatment for BD that should be evaluated in further studies.
American Psychological Association (APA)
Gaitanis, Georgios& Tsironi, Theodora& Spyridonos, Panagiota& Bassukas, Ioannis D.. 2018. A Case Series of Bowen’s Disease Treated with the Combination of Cryosurgery and Ingenol Mebutate and Followed Up with Optical Coherence Tomography. Case Reports in Dermatological Medicine،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1142862
Modern Language Association (MLA)
Gaitanis, Georgios…[et al.]. A Case Series of Bowen’s Disease Treated with the Combination of Cryosurgery and Ingenol Mebutate and Followed Up with Optical Coherence Tomography. Case Reports in Dermatological Medicine No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1142862
American Medical Association (AMA)
Gaitanis, Georgios& Tsironi, Theodora& Spyridonos, Panagiota& Bassukas, Ioannis D.. A Case Series of Bowen’s Disease Treated with the Combination of Cryosurgery and Ingenol Mebutate and Followed Up with Optical Coherence Tomography. Case Reports in Dermatological Medicine. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1142862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142862