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Does the Intensity of IGG4 Immunostaining Have a Correlation with the Clinical Presentation of Riedel’s Thyroiditis?
Joint Authors
Simões, C. A.
Tavares, M. R.
Andrade, N. M. M.
Uehara, T. M.
Cernea, C. R.
Dedivitis, Rogério Aparecido
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-16
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Riedel’s thyroiditis (RT) represents one type of IgG4-related thyroid disease (IgG4RTD) and the diagnosis involves quantitative immunohistochemistry showing dense lymphoplasmacellular inflammatory infiltrate consisting of IgG4-positive plasma cells with storiform fibrosis and obliterative phlebitis.
We report a case of RT with progressive enlargement of the anterior neck, severe dysphagia, odynophagia, and dyspnea.
The patient underwent surgical decompression of the airway, protection tracheotomy, and gastrostomy for nutritional intake 6 months after first symptoms.
Complete resolution occurred after surgical treatment combined with prednisolone.
Immunostaining revealed IgG4-positive plasma cells 12/HPF (high-power field) and the IgG4/IgG ratio 25%, values that were disproportionate to the intensity of the patient’s symptoms.
As to this case and the few cases described and analyzed in the literature, our impression is that there is no relation between the intensity of symptoms in RT with the total number of IgG4-positive plasma cells and the IgG4/IgG ratio, but more studies are needed.
American Psychological Association (APA)
Simões, C. A.& Tavares, M. R.& Andrade, N. M. M.& Uehara, T. M.& Dedivitis, Rogério Aparecido& Cernea, C. R.. 2018. Does the Intensity of IGG4 Immunostaining Have a Correlation with the Clinical Presentation of Riedel’s Thyroiditis?. Case Reports in Endocrinology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1142956
Modern Language Association (MLA)
Simões, C. A.…[et al.]. Does the Intensity of IGG4 Immunostaining Have a Correlation with the Clinical Presentation of Riedel’s Thyroiditis?. Case Reports in Endocrinology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1142956
American Medical Association (AMA)
Simões, C. A.& Tavares, M. R.& Andrade, N. M. M.& Uehara, T. M.& Dedivitis, Rogério Aparecido& Cernea, C. R.. Does the Intensity of IGG4 Immunostaining Have a Correlation with the Clinical Presentation of Riedel’s Thyroiditis?. Case Reports in Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1142956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142956