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Treatment of Concurrent Thrombotic Thrombocytopenic Purpura and Graves’ Disease: A Report on Two Cases
Joint Authors
Lhotta, Karl
Sprenger-Mähr, Hannelore
Zitt, Emanuel
Loacker, Lorin
Becherer, Alexander
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-09
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Graves’ disease (GD) and thrombotic thrombocytopenic purpura (TTP) are autoimmune diseases caused by autoantibodies against the TSH receptor (TRAb) and the enzyme ADAMTS13.
We here report on two patients with concurrent GD and TTP, who achieved sustained remission of both conditions with the TTP treatment regimen and thiamazole.
Both patients suffered from relapsing TTP and were diagnosed with GD concomitantly at the time of relapse.
They were treated with steroids, plasma exchange, rituximab, and thiamazole.
This therapy induced complete remission of TTP.
TRAb levels also decreased rapidly and both patients developed subclinical hypothyroidism three and five weeks later.
Our observations suggest that TTP and GD may be concomitant and that GD possibly triggers a relapse of TTP.
The combination of thyrostatic treatment and immunosuppression with PE, rituximab, and steroids is able to induce rapid and prolonged remission of GD.
American Psychological Association (APA)
Lhotta, Karl& Zitt, Emanuel& Sprenger-Mähr, Hannelore& Loacker, Lorin& Becherer, Alexander. 2018. Treatment of Concurrent Thrombotic Thrombocytopenic Purpura and Graves’ Disease: A Report on Two Cases. Case Reports in Endocrinology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1142991
Modern Language Association (MLA)
Lhotta, Karl…[et al.]. Treatment of Concurrent Thrombotic Thrombocytopenic Purpura and Graves’ Disease: A Report on Two Cases. Case Reports in Endocrinology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1142991
American Medical Association (AMA)
Lhotta, Karl& Zitt, Emanuel& Sprenger-Mähr, Hannelore& Loacker, Lorin& Becherer, Alexander. Treatment of Concurrent Thrombotic Thrombocytopenic Purpura and Graves’ Disease: A Report on Two Cases. Case Reports in Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1142991
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142991