Difficulties of Management of Multiple Synchronous Bone Tumors in Li-Fraumeni Syndrome
Joint Authors
Brugieres, Laurence
Gaspar, Nathalie
Huby, Marine
Mascard, Eric
Pannier, Stéphanie
Aurégan, Jean-Charles
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Li-Fraumeni syndrome is a rare inherited disease characterized by the early onset of multiple primary malignant tumors.
Sarcomas account for more than 30% of all malignant tumors occurring at pediatric age.
Furthermore, it was shown that the rates of second cancer were higher in childhood cancer survivors.
We report the case of a patient with Li-Fraumeni syndrome who was referred to us with three synchronous skeletal tumors.
This unique situation led to difficulties for the medical team regarding the diagnosis of malignancy and the surgical treatment to propose.
The discovery of multiple lesions in the extension assessment underlines the usefulness of whole-body imaging for the follow-up of patients with germline TP53 mutations.
Most recent guidelines now recommend annual whole-body MRI for screening for cancer patients carrying germline TP53.
With this report, we aim to share our experience with this rare situation in order to improve care about these specific cases.
American Psychological Association (APA)
Huby, Marine& Brugieres, Laurence& Mascard, Eric& Gaspar, Nathalie& Pannier, Stéphanie& Aurégan, Jean-Charles. 2019. Difficulties of Management of Multiple Synchronous Bone Tumors in Li-Fraumeni Syndrome. Case Reports in Orthopedics،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1143058
Modern Language Association (MLA)
Huby, Marine…[et al.]. Difficulties of Management of Multiple Synchronous Bone Tumors in Li-Fraumeni Syndrome. Case Reports in Orthopedics No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1143058
American Medical Association (AMA)
Huby, Marine& Brugieres, Laurence& Mascard, Eric& Gaspar, Nathalie& Pannier, Stéphanie& Aurégan, Jean-Charles. Difficulties of Management of Multiple Synchronous Bone Tumors in Li-Fraumeni Syndrome. Case Reports in Orthopedics. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1143058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143058