Tumor Necrosis Factor Alpha Inhibition for Inflammatory Bowel Disease after Liver Transplant for Primary Sclerosing Cholangitis
Joint Authors
Abdulhamid, Ahmed
Trudeau, Sheri
Kaur, Nirmal
Parekh, Ravish
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Outcome data regarding the use of tumor necrosis factor alpha inhibitors (anti-TNFα) in patients with inflammatory bowel disease (IBD) after liver transplant (LT) for primary sclerosing cholangitis (PSC) are scant.
Methods.
We performed a retrospective chart review to investigate outcomes among a series of post-liver-transplant PSC/IBD patients receiving anti-TNFα therapy at Henry Ford Health System ((HFHS), Detroit, MI).
Results.
A total of five patients were treated with anti-TNFα agents for IBD after LT for PSC from 1993 through 2015.
Two patients were treated with adalimumab, and three were treated with infliximab.
Three patients were hospitalized with severe posttransplant infections.
Two patients developed posttransplant lymphoproliferative disease (PTLD); one of these patients died due to complications of PTLD.
Conclusion.
Anti-TNFα treatment following LT worsened the disease course in our patients with concurrent PSC/IBD and led to serious complications and surgical intervention.
Larger studies are needed to evaluate the side effects and outcomes of the use of such agents in this patient population.
Until then, clinicians should have a high threshold to use anti-TNFα therapy in this setting.
American Psychological Association (APA)
Parekh, Ravish& Abdulhamid, Ahmed& Trudeau, Sheri& Kaur, Nirmal. 2018. Tumor Necrosis Factor Alpha Inhibition for Inflammatory Bowel Disease after Liver Transplant for Primary Sclerosing Cholangitis. Case Reports in Gastrointestinal Medicine،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1143377
Modern Language Association (MLA)
Parekh, Ravish…[et al.]. Tumor Necrosis Factor Alpha Inhibition for Inflammatory Bowel Disease after Liver Transplant for Primary Sclerosing Cholangitis. Case Reports in Gastrointestinal Medicine No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1143377
American Medical Association (AMA)
Parekh, Ravish& Abdulhamid, Ahmed& Trudeau, Sheri& Kaur, Nirmal. Tumor Necrosis Factor Alpha Inhibition for Inflammatory Bowel Disease after Liver Transplant for Primary Sclerosing Cholangitis. Case Reports in Gastrointestinal Medicine. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1143377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143377