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A Case of Acute Autoimmune Hepatitis Superimposed on Chronic Hepatitis B Infection
Joint Authors
Patel, Hiren
Sostre, Vanessa
Mohamed, Abdalla
Volfson, Ariy
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-01
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Autoimmune hepatitis has been associated with chronic HCV infection, but there are only few cases reported of HBV infection as a possible trigger.
We present a case of a young male who was diagnosed with acute autoimmune hepatitis superimposed on existent chronic HBV infection.
A 30-year-old Hispanic male with no past medical history presented to the hospital with complaints of few days of generalized weakness.
Laboratory findings were significant for elevated liver enzymes: AST, 1164 U/L; ALT, 1461 U/L; total bilirubin, 2 MG/DL; and alkaline phosphatase, 75 IU/L.
Extensive workup was done to find the etiology for elevated liver enzymes.
Only blood work that came back positive was for chronic HBV infection and elevated immunoglobulin G (IgG) level 1937 mg/dL.
HBV viral load was 42,900,000 IU/mL.
The patient was started on tenofovir 300 mg daily.
Liver biopsy was done which was consistent with autoimmune hepatitis.
Prednisone 60 mg daily was started.
Six months later, blood work showed completely normal liver enzymes and total IgG.
Hepatotropic viruses have been proposed as triggering factors for several autoimmune diseases.
There are theories suggesting that similarity in viral epitope and self-proteins expression on liver cells’ surface causes a cross-reactive immunologic response and possible viral-induced autoimmune hepatitis.
American Psychological Association (APA)
Sostre, Vanessa& Patel, Hiren& Mohamed, Abdalla& Volfson, Ariy. 2018. A Case of Acute Autoimmune Hepatitis Superimposed on Chronic Hepatitis B Infection. Case Reports in Gastrointestinal Medicine،Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1143398
Modern Language Association (MLA)
Sostre, Vanessa…[et al.]. A Case of Acute Autoimmune Hepatitis Superimposed on Chronic Hepatitis B Infection. Case Reports in Gastrointestinal Medicine No. 2018 (2018), pp.1-3.
https://search.emarefa.net/detail/BIM-1143398
American Medical Association (AMA)
Sostre, Vanessa& Patel, Hiren& Mohamed, Abdalla& Volfson, Ariy. A Case of Acute Autoimmune Hepatitis Superimposed on Chronic Hepatitis B Infection. Case Reports in Gastrointestinal Medicine. 2018. Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1143398
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143398