Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile
Joint Authors
Koopmansch, Caroline
Maris, Calliope
Demetter, Pieter
Van de Stadt, Jean
Hendlisz, Alain
D’Haene, Nicky
Noël, Jean-Christophe
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Differentiated-type Intraepithelial Neoplasia (DIN) is defined as HPV-negative squamous intraepithelial proliferation with abnormal keratinocyte differentiation and basal cell atypia, originally described in the vulva, with following descriptions in the oral cavity.
DIN occurring in the anus is quite rare, and to the best of our knowledge, only one publication reported it.
In this report, we describe the clinicopathological features of this entity on anal margin, associated with invasive squamous cell carcinoma.
In addition, using the next generation sequencing (NGS) technique, we have demonstrated TP53 mutation in the invasive component but not in the associated DIN-like lesion, where p53 immunohistochemical expression was restricted to basal layers.
American Psychological Association (APA)
Koopmansch, Caroline& Maris, Calliope& Demetter, Pieter& Van de Stadt, Jean& Hendlisz, Alain& D’Haene, Nicky…[et al.]. 2019. Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile. Case Reports in Pathology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1143420
Modern Language Association (MLA)
Koopmansch, Caroline…[et al.]. Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile. Case Reports in Pathology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1143420
American Medical Association (AMA)
Koopmansch, Caroline& Maris, Calliope& Demetter, Pieter& Van de Stadt, Jean& Hendlisz, Alain& D’Haene, Nicky…[et al.]. Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile. Case Reports in Pathology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1143420
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143420