An Unusual Hybrid Salivary Gland Tumor: Molecular Analysis Informs the Potential Pathogenesis of This Rare Neoplasm
Joint Authors
Zhou, Yan
Martinez Duarte, Ernesto
Eleff, David J.
Tafe, Laura J.
Leibowitz, Jason M.
Kerr, Darcy A.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
The presence of two or more tumor entities growing in adjacent locations within the salivary gland is very rare, and pathologic studies on such lesions are limited, particularly those with molecular information.
Since the clinical history and imaging studies are usually nonspecific, accurate diagnosis and clinical management largely depend on a thorough histological examination.
Methods and Results.
We describe a 71-year-old man with an unusual case of hybrid salivary gland tumor composed of mucoepidermoid carcinoma and basal cell adenoma.
Molecular analysis revealed differing driver genetic alterations in each component.
Conclusions.
Hybrid salivary gland tumors are rare, and their pathogenesis is controversial.
The combination of mucoepidermoid carcinoma and basal cell adenoma has not been previously described.
While malignant transformation of adenoma to carcinoma seems plausible, gene sequencing was more suggestive of their independent derivation.
Key to appropriate surgical management is identifying the more aggressive component, ideally at the time of intraoperative consultation.
American Psychological Association (APA)
Zhou, Yan& Martinez Duarte, Ernesto& Eleff, David J.& Tafe, Laura J.& Leibowitz, Jason M.& Kerr, Darcy A.. 2019. An Unusual Hybrid Salivary Gland Tumor: Molecular Analysis Informs the Potential Pathogenesis of This Rare Neoplasm. Case Reports in Pathology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1143432
Modern Language Association (MLA)
Zhou, Yan…[et al.]. An Unusual Hybrid Salivary Gland Tumor: Molecular Analysis Informs the Potential Pathogenesis of This Rare Neoplasm. Case Reports in Pathology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1143432
American Medical Association (AMA)
Zhou, Yan& Martinez Duarte, Ernesto& Eleff, David J.& Tafe, Laura J.& Leibowitz, Jason M.& Kerr, Darcy A.. An Unusual Hybrid Salivary Gland Tumor: Molecular Analysis Informs the Potential Pathogenesis of This Rare Neoplasm. Case Reports in Pathology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1143432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143432