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Anti-PD-1 Therapy-Associated Perforating Colitis
Joint Authors
Kluger, Harriet M.
Celli, Romulo
Zhang, Xuchen
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-31
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Inhibition of immune checkpoint T cell regulatory molecules by using programmed cell death protein 1 (PD-1), or its ligand (PDL-1), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) has been increasingly used to treat advanced malignancies.
The immune-related adverse effects associated with these treatments such as diarrhea, colitis, and CTLA-4 treatment-associated perforating colitis have been reported.
However, anti-PD-1/PD-L1-associated perforating colitis has rarely been reported.
We report a case of colonic perforation in a patient recently treated with pembrolizumab, a PD-1 inhibitor for metastatic melanoma.
Awareness of anti-PD-1/PD-L1-associated colitis and perforation will facilitate a timely diagnosis and management as they are increasingly used in oncology.
American Psychological Association (APA)
Celli, Romulo& Kluger, Harriet M.& Zhang, Xuchen. 2018. Anti-PD-1 Therapy-Associated Perforating Colitis. Case Reports in Gastrointestinal Medicine،Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1143454
Modern Language Association (MLA)
Celli, Romulo…[et al.]. Anti-PD-1 Therapy-Associated Perforating Colitis. Case Reports in Gastrointestinal Medicine No. 2018 (2018), pp.1-3.
https://search.emarefa.net/detail/BIM-1143454
American Medical Association (AMA)
Celli, Romulo& Kluger, Harriet M.& Zhang, Xuchen. Anti-PD-1 Therapy-Associated Perforating Colitis. Case Reports in Gastrointestinal Medicine. 2018. Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1143454
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143454