Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature
Joint Authors
Jana, Tanima
Pan, Jen-Jung
Mukherjee, Subhajit
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Proton pump inhibitors (PPIs) are the most effective and preferred class of drugs used to treat peptic ulcer disease, gastroesophageal reflux disease, and other diseases associated with increased production of gastric acid.
PPIs in general have an excellent long-term safety profile and are well-tolerated.
However, studies have shown some adverse reactions (e.g., osteoporosis, Clostridium difficile-associated diarrhea, Vitamin B12 and iron deficiency, and acute interstitial nephritis) on long-term PPI use.
Thrombocytopenia attributed to use of PPIs has been described in a few case reports and a retrospective study.
In this case report, we describe a case of PPI-induced thrombocytopenia.
In our patient, thrombocytopenia immediately developed after the initiation of PPI on two separate occasions and resolved after its discontinuation.
The strong association found in our case implies the potential role of PPI in causing this rare but serious adverse reaction.
Based on this case report and the observation from other studies, a PPI-induced adverse event should be considered as a possible etiology for new-onset idiopathic thrombocytopenia.
American Psychological Association (APA)
Mukherjee, Subhajit& Jana, Tanima& Pan, Jen-Jung. 2018. Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature. Case Reports in Gastrointestinal Medicine،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1143470
Modern Language Association (MLA)
Mukherjee, Subhajit…[et al.]. Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature. Case Reports in Gastrointestinal Medicine No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1143470
American Medical Association (AMA)
Mukherjee, Subhajit& Jana, Tanima& Pan, Jen-Jung. Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature. Case Reports in Gastrointestinal Medicine. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1143470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143470