Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass
Joint Authors
Lin, Grace
Tipps, Ann
Gordhandas, Jeenal
Zare, Somaye Y.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-15
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Dedifferentiated liposarcomas most commonly arise in the retroperitoneum, accounting for 10% of liposarcomas.
Heterologous differentiation occurs in 5-10% of dedifferentiated liposarcomas; however, divergent osteosarcomatous differentiation is rare.
We report a rare case of initial presentation of dedifferentiated liposarcoma with osteosarcomatous component as a colonic mass in a 72-year-old man.
The tumor is mainly composed of bony trabeculae with intervening highly atypical cells and adjacent high-grade mesenchymal nonlipogenic tumor, as well as areas of well-differentiated liposarcoma.
Immunohistochemical studies showed diffuse positivity for SATB2 in the atypical cells and fluorescence in situ hybridization revealed high-level amplification of MDM2 gene, supporting the diagnosis of well-differentiated and dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation.
American Psychological Association (APA)
Gordhandas, Jeenal& Lin, Grace& Tipps, Ann& Zare, Somaye Y.. 2019. Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass. Case Reports in Pathology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1143552
Modern Language Association (MLA)
Gordhandas, Jeenal…[et al.]. Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass. Case Reports in Pathology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1143552
American Medical Association (AMA)
Gordhandas, Jeenal& Lin, Grace& Tipps, Ann& Zare, Somaye Y.. Osteosarcomatous Divergence in Dedifferentiated Liposarcoma Presenting as a Colonic Mass. Case Reports in Pathology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1143552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143552