![](/images/graphics-bg.png)
Sagittal Craniosynostosis with Uncommon Anatomical Pathologies in a 56-Year-Old Male Cadaver
Joint Authors
Frolov, Andrey
Lawson, Craig
Olatunde, Joshua
Goodrich, James T.
Martin III, John R.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sagittal craniosynostosis (CS) is a pathologic condition that results in premature fusion of the sagittal suture, restricting the transverse growth of the skull leading in some cases to elevated intracranial pressure and neurodevelopmental delay.
There is still much to be learned about the etiology of CS.
Here, we report a case of 56-year-old male cadaver that we describe as sagittal CS with torus palatinus being an additional anomaly.
The craniotomy was unsuccessful (cephalic index, CI = 56) and resulted in abnormal vertical outgrowth of the craniotomized bone strip.
The histological analysis of the latter revealed atypical, noncompensatory massive bone overproduction.
Exome sequencing of DNA extracted from the cadaveric tissue specimen performed on the Next Generation Sequencing (NGS) platform yielded 81 genetic variants identified as pathologic.
Nine of those variants could be directly linked to CS with five of them targeting RhoA GTPase signaling, with a potential to make it sustained in nature.
The latter could trigger upregulated calvarial osteogenesis leading to premature suture fusion, skull bone thickening, and craniotomized bone strip outgrowth observed in the present case.
American Psychological Association (APA)
Frolov, Andrey& Lawson, Craig& Olatunde, Joshua& Goodrich, James T.& Martin III, John R.. 2019. Sagittal Craniosynostosis with Uncommon Anatomical Pathologies in a 56-Year-Old Male Cadaver. Case Reports in Pathology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1143560
Modern Language Association (MLA)
Frolov, Andrey…[et al.]. Sagittal Craniosynostosis with Uncommon Anatomical Pathologies in a 56-Year-Old Male Cadaver. Case Reports in Pathology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1143560
American Medical Association (AMA)
Frolov, Andrey& Lawson, Craig& Olatunde, Joshua& Goodrich, James T.& Martin III, John R.. Sagittal Craniosynostosis with Uncommon Anatomical Pathologies in a 56-Year-Old Male Cadaver. Case Reports in Pathology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1143560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143560