Central Precocious Puberty as a Complication of Therapy with Adrenocorticotropin (ACTH) and an Aromatase Inhibitor for Refractory Nephrotic Syndrome
Joint Authors
Agrawal, Sungeeta
Gensure, Robert
Milner, Lawrence
Nicoletta, Julie
Sadeghi-Nejad, Abdollah
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-04
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Glucocorticoids are typically prescribed for the treatment of idiopathic nephrotic syndrome of childhood.
In selected patients with refractory focal segmental glomuerulosclerosis (FSGS), adrenocorticotropin (ACTH) can be used to induce remission and decrease the progression of the disease.
We report a 6 8/12-year-old girl with recurrent proteinuria, resistant to standard immunotherapy.
She underwent related renal transplant but again developed proteinuria and was started on ACTH.
She subsequently developed peripheral precocious puberty (PPP), presumably from peripheral aromatization of adrenal androgens.
She was started on an aromatase inhibitor, and her ACTH dose was slowly decreased.
She then developed central precocious puberty (CPP).
We hypothesize that treatment of her peripheral precocious puberty with an aromatase inhibitor may have triggered central precocious puberty.
American Psychological Association (APA)
Agrawal, Sungeeta& Gensure, Robert& Milner, Lawrence& Nicoletta, Julie& Sadeghi-Nejad, Abdollah. 2019. Central Precocious Puberty as a Complication of Therapy with Adrenocorticotropin (ACTH) and an Aromatase Inhibitor for Refractory Nephrotic Syndrome. Case Reports in Pediatrics،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1143640
Modern Language Association (MLA)
Agrawal, Sungeeta…[et al.]. Central Precocious Puberty as a Complication of Therapy with Adrenocorticotropin (ACTH) and an Aromatase Inhibitor for Refractory Nephrotic Syndrome. Case Reports in Pediatrics No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1143640
American Medical Association (AMA)
Agrawal, Sungeeta& Gensure, Robert& Milner, Lawrence& Nicoletta, Julie& Sadeghi-Nejad, Abdollah. Central Precocious Puberty as a Complication of Therapy with Adrenocorticotropin (ACTH) and an Aromatase Inhibitor for Refractory Nephrotic Syndrome. Case Reports in Pediatrics. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1143640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143640
