A Challenging Case of Severe Ulcerative Colitis following the Initiation of Secukinumab for Ankylosing Spondylitis
Joint Authors
Pisegna, Joseph R.
Ehrlich, Dean
Jamaluddin, Nimah
Padua, David
Source
Case Reports in Gastrointestinal Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-15
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Secukinumab is an interleukin-17 inhibitor used for the treatment of ankylosing spondylitis (AS), psoriasis, and psoriatic arthritis.
The risk of exacerbating underlying inflammatory bowel disease (IBD) in patients being treated with secukinumab for other conditions is controversial.
We document a patient with AS and previously undiagnosed IBD, found to be in a severe ulcerative colitis flare shortly after receiving the loading dose of secukinumab.
There are no guidelines regarding biologic salvage therapy for IBD in the setting of active treatment with another biologic agent.
After waiting one half-life of secukinumab, our patient had an excellent response to initiation of infliximab.
American Psychological Association (APA)
Ehrlich, Dean& Jamaluddin, Nimah& Pisegna, Joseph R.& Padua, David. 2018. A Challenging Case of Severe Ulcerative Colitis following the Initiation of Secukinumab for Ankylosing Spondylitis. Case Reports in Gastrointestinal Medicine،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1143694
Modern Language Association (MLA)
Ehrlich, Dean…[et al.]. A Challenging Case of Severe Ulcerative Colitis following the Initiation of Secukinumab for Ankylosing Spondylitis. Case Reports in Gastrointestinal Medicine No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1143694
American Medical Association (AMA)
Ehrlich, Dean& Jamaluddin, Nimah& Pisegna, Joseph R.& Padua, David. A Challenging Case of Severe Ulcerative Colitis following the Initiation of Secukinumab for Ankylosing Spondylitis. Case Reports in Gastrointestinal Medicine. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1143694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143694
