Composite Lymphoma Comprising Extranodal NKT-Cell Lymphoma and Diffuse Large B-Cell Lymphoma

Abstract EN

We report a rare case of composite lymphoma comprising extranodal NK/T-cell lymphoma, nasal type, (ENKL) and diffuse large B-cell lymphoma (DLBCL) in a 70-year-old man complaining of fatigue.

Computed tomography showed multiple consolidations in both lungs, and ENKL was diagnosed from transbronchial lung biopsy.

Positron emission tomography also detected abnormal uptake in the stomach, and DLBCL was diagnosed from subsequent gastroscopy.

Two courses of chemotherapy including rituximab achieved reduction in DLBCL, but ENKL proved resistant to this treatment and progressed.

Concomitant ENKL and DLBCL have not been previously described among reports of composite lymphomas.