Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation
Joint Authors
Hovland, Randi
Gjertsen, B. T.
Reikvam, Håkon
Skavland, Jørn
Gullaksen, Stein-Erik
Gedde-Dahl, Tobias
Bruserud, Øystein
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-23
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Chronic myeloid leukemia (CML) is a myeloproliferative disorder in which neoplastic cells exhibit the Philadelphia chromosome and the related oncoprotein BCR-ABL1.
Allogeneic stem cell transplantation (allo-SCT) was considered the first-line treatment for CML, before the introduction of tyrosine kinase inhibitors (TKIs).
However, patients are at risk for relapse years after transplantation.
We present a patient who relapsed 25 years after allo-SCT for chronic phase CML.
Polymerase chain reaction (PCR) detected gradually evaluated levels of BCR-ABL1 transcripts, eventually leading to the diagnosis of relapsed disease.
Additional mutational analyses did not reveal mutations in the BCR-ABL1 gene, or other cooperating mutations.
The patient was successfully treated with imatinib 400 mg daily, leading to new molecular remission.
The case presentation emphasizes the need for long-term follow-up of such patients and the potential benefit of initiating TKI treatment with early signs of relapse.
American Psychological Association (APA)
Reikvam, Håkon& Skavland, Jørn& Gullaksen, Stein-Erik& Hovland, Randi& Gedde-Dahl, Tobias& Bruserud, Øystein…[et al.]. 2018. Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1143757
Modern Language Association (MLA)
Reikvam, Håkon…[et al.]. Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation. Case Reports in Hematology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1143757
American Medical Association (AMA)
Reikvam, Håkon& Skavland, Jørn& Gullaksen, Stein-Erik& Hovland, Randi& Gedde-Dahl, Tobias& Bruserud, Øystein…[et al.]. Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1143757
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143757