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Treatment of Bleeding Diathesis Associated with a Heparin-Like Anticoagulant in Plasma Cell Neoplasia Using Protamine
Joint Authors
Willner, Christopher A.
Chisti, Mohammed M.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-13
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
The development of a heparin-like anticoagulant (HLAC) in plasma cell neoplasia has previously been described in clinical literature.
Testing of this HLAC, primarily in vitro, has demonstrated that neutralization may be achieved with protamine sulfate, owing to antithrombin III cofactor activity.
We report a case in which intravenous protamine sulfate was administered to a patient with IgG-kappa monotypic multiple myeloma, which resulted in resolution of bleeding and coagulopathy, confirmed via objective laboratory data.
Our case is intended to demonstrate that intravenous protamine sulfate should be considered in acute bleeding with plasma cell neoplasia.
We review the literature to observe past experiences about this phenomenon.
We postulate that chemotherapy, targeted therapies, and immunotherapies may also disrupt production of a HLAC.
With further investigation, this strategy could be applicable in other hematological malignancies with bleeding diathesis, chiefly if the pathophysiology of the HLAC is precisely defined.
American Psychological Association (APA)
Willner, Christopher A.& Chisti, Mohammed M.. 2018. Treatment of Bleeding Diathesis Associated with a Heparin-Like Anticoagulant in Plasma Cell Neoplasia Using Protamine. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1143844
Modern Language Association (MLA)
Willner, Christopher A.& Chisti, Mohammed M.. Treatment of Bleeding Diathesis Associated with a Heparin-Like Anticoagulant in Plasma Cell Neoplasia Using Protamine. Case Reports in Hematology No. 2018 (2018), pp.1-3.
https://search.emarefa.net/detail/BIM-1143844
American Medical Association (AMA)
Willner, Christopher A.& Chisti, Mohammed M.. Treatment of Bleeding Diathesis Associated with a Heparin-Like Anticoagulant in Plasma Cell Neoplasia Using Protamine. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1143844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143844