A Case of Myeloproliferative Neoplasm with BCR-FGFR1 Rearrangement: Favorable Outcome after Haploidentical Allogeneic Transplantation
Joint Authors
Villafuerte-Gutierrez, Paola
López Rubio, Montserrat
Herrera, Pilar
Arranz, Eva
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-06
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Hematopoietic myeloproliferative neoplasms with FGFR1 rearrangement result in the 8p11 myeloproliferative syndrome that in the current Word Health Organization classification is designated as “myeloid and lymphoid neoplasm with FGFR1 abnormalities.” We report the case of a 66-year-old man who had clinical features that resembled chronic myeloid leukaemia (CML), but bone marrow cytogenetic and fluorescent in situ hybridization (FISH) studies showed t(8;22)(p11;q11) and BCR-FGFR1 fusion gene.
He was initially managed with hydroxyurea, and given the aggressive nature of this disease, four months later, the patient underwent an allogeneic hematopoietic stem-cell transplantation (HSCT) from an HLA-haploidentical relative.
Currently, HSCT may be the only therapeutic option for long-term survival at least until more efficacious tyrosine kinase inhibitors (TKIs) become available.
American Psychological Association (APA)
Villafuerte-Gutierrez, Paola& López Rubio, Montserrat& Herrera, Pilar& Arranz, Eva. 2018. A Case of Myeloproliferative Neoplasm with BCR-FGFR1 Rearrangement: Favorable Outcome after Haploidentical Allogeneic Transplantation. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1143895
Modern Language Association (MLA)
Villafuerte-Gutierrez, Paola…[et al.]. A Case of Myeloproliferative Neoplasm with BCR-FGFR1 Rearrangement: Favorable Outcome after Haploidentical Allogeneic Transplantation. Case Reports in Hematology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1143895
American Medical Association (AMA)
Villafuerte-Gutierrez, Paola& López Rubio, Montserrat& Herrera, Pilar& Arranz, Eva. A Case of Myeloproliferative Neoplasm with BCR-FGFR1 Rearrangement: Favorable Outcome after Haploidentical Allogeneic Transplantation. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1143895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143895