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Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall
Joint Authors
Chapman-Fredericks, Jennifer
Vega, Francisco
Algashaamy, Khaled
Tan, Yaohong
Mackrides, Nicolas
Alencar, Alvaro
Peng, Jing-Hong
Alderuccio, Juan P
Lossos, Izidore S.
Rosenblatt, Joseph D.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Prolymphocytic transformation is a concept usually applied in the context of chronic lymphocytic leukemia/small lymphocytic lymphoma to describe the presence of a high percentage of prolymphocytes in peripheral blood (usually more than 55%).
Prolymphocytic transformation has also been reported in mantle cell lymphoma (MCL) but only rarely in splenic marginal zone lymphoma (SMZL).
We present two splenic B-cell lymphomas presenting in the leukemic phase and with increased prolymphocytes, both classified as SMZL with prolymphocytic transformation.
One case clinically simulated B-prolymphocytic leukemia (B-PLL).
Both lymphomas were very unusual because the tumor cells diffusely and strongly expressed cyclin D1 despite lacking the t(11; 14)(q13; q32) as detected by several approaches including next-generation sequencing, fluorescence in situ hybridization using CCND1 break apart probe and fusion probes for t(11; 14)(q13; q32), and conventional karyotyping.
These cases therefore simulated prolymphocytic variants of MCL.
The incidence of this phenomenon is unknown, and awareness of this potential alternate protein expression pattern is important in order to avoid diagnostic errors.
American Psychological Association (APA)
Algashaamy, Khaled& Tan, Yaohong& Mackrides, Nicolas& Alencar, Alvaro& Peng, Jing-Hong& Rosenblatt, Joseph D.…[et al.]. 2018. Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1143902
Modern Language Association (MLA)
Algashaamy, Khaled…[et al.]. Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall. Case Reports in Hematology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1143902
American Medical Association (AMA)
Algashaamy, Khaled& Tan, Yaohong& Mackrides, Nicolas& Alencar, Alvaro& Peng, Jing-Hong& Rosenblatt, Joseph D.…[et al.]. Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1143902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143902