Chronic Lymphocytic Leukemia and Myelofibrosis
Joint Authors
Atlan, Karine
Darawshy, Fares
Ben-Yehuda, Arieh
Rund, Deborah
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Chronic lymphocytic lymphoma (CLL) can be associated with several malignancies, but rarely with myelofibrosis.
Only isolated case reports in the literature described the association between CLL and primary myelofibrosis (PMF) in the same patient.
Objectives.
We describe a case of CLL characterized by the development of PMF and a review of literature.
Methods.
We describe an 86-year-old female diagnosed as having CLL and followed by the development of splenomegaly and progressively rising LDH levels 27 months later.
A bone marrow biopsy was consistent with the diagnosis of PMF, with positive JAK-2 V617F mutation.
We also review the clinical and molecular characteristics of patients with CLL and PMF.
Results.
Patients with CLL and PMF are usually older.
A lead diagnosis of CLL harbored by PMF is the most common clinical course, although concomitant diseases may occur in 31.7% of patients.
JAK-2 V617F mutation can be found in 48.7% of patients.
Conclusion.
This case reported here constitutes an unusual situation of CLL characterized by the development of PMF.
Etiologic and pathogenic associations—the role of t (1; 6) and JAK-2 V617F mutation—are discussed.
American Psychological Association (APA)
Darawshy, Fares& Ben-Yehuda, Arieh& Atlan, Karine& Rund, Deborah. 2018. Chronic Lymphocytic Leukemia and Myelofibrosis. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1143989
Modern Language Association (MLA)
Darawshy, Fares…[et al.]. Chronic Lymphocytic Leukemia and Myelofibrosis. Case Reports in Hematology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1143989
American Medical Association (AMA)
Darawshy, Fares& Ben-Yehuda, Arieh& Atlan, Karine& Rund, Deborah. Chronic Lymphocytic Leukemia and Myelofibrosis. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1143989
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143989