An Unprecedented Case of p190 BCR-ABL Chronic Myeloid Leukemia Diagnosed during Treatment for Multiple Myeloma: A Case Report and Review of the Literature

Joint Authors

Kurita, Naoki
Yokoyama, Yasuhisa
Nishikii, Hidekazu
Sakamoto, Tatsuhiro
Kusakabe, Manabu
Miki, Kosuke
Makishima, Kenichi
Kato, Takayasu
Chiba, Shigeru
Obara, Naoshi
Hasegawa, Yuichi
Sakata-Yanagimoto, Mamiko

Source

Case Reports in Hematology

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-10-10

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Diseases

Abstract EN

We report the case of a 76-year-old man who was diagnosed as having chronic myeloid leukemia (CML) with p190 BCR-ABL while receiving treatment for symptomatic multiple myeloma (MM).

The diagnosis of MM was based on the presence of serum M-protein, abnormal plasma cells in the bone marrow, and lytic bone lesions.

The patient achieved a partial response to lenalidomide and dexamethasone treatment.

However, 2 years after the diagnosis of MM, the patient developed leukocytosis with granulocytosis, anemia, and thrombocytopenia.

Bone marrow examination revealed Philadelphia chromosomes and chimeric p190 BCR-ABL mRNA.

Fluorescence in situ hybridization also revealed BCR-ABL-positive neutrophils in the peripheral blood, which suggested the emergence of CML with p190 BCR-ABL.

The codevelopment of MM and CML is very rare, and this is the first report describing p190 BCR-ABL-type CML coexisting with MM.

Moreover, we have reviewed the literature regarding the coexistence of these diseases.

American Psychological Association (APA)

Miki, Kosuke& Obara, Naoshi& Makishima, Kenichi& Sakamoto, Tatsuhiro& Kusakabe, Manabu& Kato, Takayasu…[et al.]. 2018. An Unprecedented Case of p190 BCR-ABL Chronic Myeloid Leukemia Diagnosed during Treatment for Multiple Myeloma: A Case Report and Review of the Literature. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1144018

Modern Language Association (MLA)

Miki, Kosuke…[et al.]. An Unprecedented Case of p190 BCR-ABL Chronic Myeloid Leukemia Diagnosed during Treatment for Multiple Myeloma: A Case Report and Review of the Literature. Case Reports in Hematology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1144018

American Medical Association (AMA)

Miki, Kosuke& Obara, Naoshi& Makishima, Kenichi& Sakamoto, Tatsuhiro& Kusakabe, Manabu& Kato, Takayasu…[et al.]. An Unprecedented Case of p190 BCR-ABL Chronic Myeloid Leukemia Diagnosed during Treatment for Multiple Myeloma: A Case Report and Review of the Literature. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1144018

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1144018