Anti-CD20 Treatment of Autoimmune Hemolytic Anemia Refractory to Corticosteroids and Azathioprine: A Pediatric Case Report and Mini Review
Joint Authors
Chaliasos, Nikolaos
Kanta, Zoi
Kalogeropoulos, Dimitrios
Makis, Alexandros
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Autoimmune hemolytic anemia (AIHA) is a relatively uncommon hematological entity in children and sometimes is characterized by a severe course requiring more than one line course therapy.
Treatment decisions depend on the severity and chronicity of the anemia and the characteristics of the autoantibodies.
Immunosuppression with corticosteroids is the first-line treatment, especially in warm-reactive AIHA.
Refractory cases are treated with immunosuppressive drugs, cytotoxic agents, androgens, or splenectomy, with various side effects and questionable efficacy.
Another second-line option is rituximab, an anti-CD20 monoclonal antibody, which has been used as an off-label agent with encouraging results from small limited studies or case reports.
Herein, we add our experience on the safety and clinical efficacy of rituximab by presenting the case of a boy with warm-type AIHA resistant to corticosteroids and azathioprine, successfully treated with rituximab.
We also offer a review of the relevant literature.
American Psychological Association (APA)
Makis, Alexandros& Kanta, Zoi& Kalogeropoulos, Dimitrios& Chaliasos, Nikolaos. 2018. Anti-CD20 Treatment of Autoimmune Hemolytic Anemia Refractory to Corticosteroids and Azathioprine: A Pediatric Case Report and Mini Review. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1144074
Modern Language Association (MLA)
Makis, Alexandros…[et al.]. Anti-CD20 Treatment of Autoimmune Hemolytic Anemia Refractory to Corticosteroids and Azathioprine: A Pediatric Case Report and Mini Review. Case Reports in Hematology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1144074
American Medical Association (AMA)
Makis, Alexandros& Kanta, Zoi& Kalogeropoulos, Dimitrios& Chaliasos, Nikolaos. Anti-CD20 Treatment of Autoimmune Hemolytic Anemia Refractory to Corticosteroids and Azathioprine: A Pediatric Case Report and Mini Review. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1144074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144074