A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia
Joint Authors
Chu, Andrew
Aung, Thu Thu
Arumugam, Minni Shreya
Danckers, Mauricio
Mitiek, Mohi
Leslie, Jonathan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Factor V Leiden (FVL) is an autosomal dominant condition resulting in thrombophilia.
Factor V normally acts as a cofactor for prothrombinase, helping cleave prothrombin to thrombin.
A single point mutation in it disrupts factor V, making it unreceptive to protein C and increasing the risk of thrombosis.
FVL mutation associated with right heart thrombus is a rare entity.
Right heart thrombus or right heart thrombus-in-transit is associated with high mortality.
We present a 51-year-old male with a past medical history of FVL homozygous mutation and recurrent blood clots, who has failed multiple different oral anticoagulants.
He presented to the hospital with symptoms of shortness of breath and subsequently found to have a giant right heart thrombus.
He was treated with surgical embolectomy.
This case underscores the challenges faced by patients with FVL and recurrent blood clots.
American Psychological Association (APA)
Chu, Andrew& Aung, Thu Thu& Arumugam, Minni Shreya& Danckers, Mauricio& Mitiek, Mohi& Leslie, Jonathan. 2018. A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1144099
Modern Language Association (MLA)
Chu, Andrew…[et al.]. A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia. Case Reports in Hematology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1144099
American Medical Association (AMA)
Chu, Andrew& Aung, Thu Thu& Arumugam, Minni Shreya& Danckers, Mauricio& Mitiek, Mohi& Leslie, Jonathan. A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1144099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144099