A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia

Joint Authors

Chu, Andrew
Aung, Thu Thu
Arumugam, Minni Shreya
Danckers, Mauricio
Mitiek, Mohi
Leslie, Jonathan

Source

Case Reports in Hematology

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-09-27

Country of Publication

Egypt

No. of Pages

4

Main Subjects

Diseases

Abstract EN

Factor V Leiden (FVL) is an autosomal dominant condition resulting in thrombophilia.

Factor V normally acts as a cofactor for prothrombinase, helping cleave prothrombin to thrombin.

A single point mutation in it disrupts factor V, making it unreceptive to protein C and increasing the risk of thrombosis.

FVL mutation associated with right heart thrombus is a rare entity.

Right heart thrombus or right heart thrombus-in-transit is associated with high mortality.

We present a 51-year-old male with a past medical history of FVL homozygous mutation and recurrent blood clots, who has failed multiple different oral anticoagulants.

He presented to the hospital with symptoms of shortness of breath and subsequently found to have a giant right heart thrombus.

He was treated with surgical embolectomy.

This case underscores the challenges faced by patients with FVL and recurrent blood clots.

American Psychological Association (APA)

Chu, Andrew& Aung, Thu Thu& Arumugam, Minni Shreya& Danckers, Mauricio& Mitiek, Mohi& Leslie, Jonathan. 2018. A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1144099

Modern Language Association (MLA)

Chu, Andrew…[et al.]. A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia. Case Reports in Hematology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1144099

American Medical Association (AMA)

Chu, Andrew& Aung, Thu Thu& Arumugam, Minni Shreya& Danckers, Mauricio& Mitiek, Mohi& Leslie, Jonathan. A Giant Right Heart Thrombus-in-Transit: The Challenge of Anticoagulation in Factor V Leiden Thrombophilia. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1144099

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1144099