Cyclin-Dependent Kinase 46 Inhibitor (Palbociclib) Induced Aplastic Anemia in a Patient with Metastatic Breast Cancer
Joint Authors
Nwabudike, Stanley Madu
Edwards, Camille V.
Akinboro, Oladimeji
Quinn, Kathryn
Sarosiek, Shayna
Ko, Naomi
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-13
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Breast cancer is the most common cancer diagnosed in women worldwide.
Over the years, breast cancer treatment has undergone revolutionary changes especially for women with hormone receptor positive metastatic disease.
As a result, women are living longer with their disease, particularly in developed countries.
The use of cyclin-dependent kinase (CDK) 4/6 inhibitors with antiestrogen therapy is a relatively new therapeutic option which has been shown to improve progression-free survival.
Hematologic adverse events, most frequently neutropenia, are well-known side effects of CDK 4/6 inhibitors.
However, to our knowledge, aplastic anemia has never been reported.
We report a case of aplastic anemia in a patient with metastatic breast cancer treated with palbociclib after multiple prior lines of therapy.
American Psychological Association (APA)
Nwabudike, Stanley Madu& Edwards, Camille V.& Akinboro, Oladimeji& Quinn, Kathryn& Sarosiek, Shayna& Ko, Naomi. 2018. Cyclin-Dependent Kinase 46 Inhibitor (Palbociclib) Induced Aplastic Anemia in a Patient with Metastatic Breast Cancer. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1144118
Modern Language Association (MLA)
Nwabudike, Stanley Madu…[et al.]. Cyclin-Dependent Kinase 46 Inhibitor (Palbociclib) Induced Aplastic Anemia in a Patient with Metastatic Breast Cancer. Case Reports in Hematology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1144118
American Medical Association (AMA)
Nwabudike, Stanley Madu& Edwards, Camille V.& Akinboro, Oladimeji& Quinn, Kathryn& Sarosiek, Shayna& Ko, Naomi. Cyclin-Dependent Kinase 46 Inhibitor (Palbociclib) Induced Aplastic Anemia in a Patient with Metastatic Breast Cancer. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1144118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144118