Acquired Coagulopathy and Hemorrhage Secondary to Subcutaneous Heparin Prophylaxis
Joint Authors
Ahuja, Tania
Sunseri, Maria
Wilcox, Tanya
Green, David
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Unfractionated heparin and low-molecular-weight heparins are commonly used as thromboprophylaxis for hospitalized patients.
Though generally considered safe at prophylactic doses, cases of catastrophic hemorrhage have been reported.
The proposed mechanism involves bioaccumulation of heparin through saturation of the rapid-elimination pathway in its metabolism.
We present an unusual case of an average-weight man with metastatic melanoma who suffered hemorrhage with syncope and end-organ damage while on prophylactic three times daily unfractionated heparin.
Coagulation studies were consistent with heparin toxicity.
Despite administration of protamine, the clearance of heparin was remarkably delayed, as demonstrated by serial coagulation studies.
We review the suspected risk factors for heparin bioaccumulation and the emerging understanding of this unusual adverse event involving a nearly ubiquitous medication.
American Psychological Association (APA)
Sunseri, Maria& Ahuja, Tania& Wilcox, Tanya& Green, David. 2018. Acquired Coagulopathy and Hemorrhage Secondary to Subcutaneous Heparin Prophylaxis. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1144126
Modern Language Association (MLA)
Sunseri, Maria…[et al.]. Acquired Coagulopathy and Hemorrhage Secondary to Subcutaneous Heparin Prophylaxis. Case Reports in Hematology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1144126
American Medical Association (AMA)
Sunseri, Maria& Ahuja, Tania& Wilcox, Tanya& Green, David. Acquired Coagulopathy and Hemorrhage Secondary to Subcutaneous Heparin Prophylaxis. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1144126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144126