Pyridostigmine Induced Prolonged Asystole in a Patient with Myasthenia Gravis Successfully Treated with Hyoscyamine
Joint Authors
Khan, Zubair
Khan, Mohammad Saud
Tiwari, Abhinav
Sharma, Himani
Hammersley, Jeffrey
Taleb, Mohammad
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-14
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Reversible acetylcholinesterase inhibitors are used as first-line treatment for myasthenia gravis.
They improve symptoms by increasing concentration of acetylcholine at the neuromuscular junction and stimulating nicotinic receptors.
Serious bradyarrhythmias can occur from muscarinic stimulation in heart, which in rare cases may progress to asystole.
These patients can initially be managed with hyoscyamine, a muscarinic antagonist.
Persistence of bradyarrhythmias even after hyoscyamine treatment may warrant pacemaker placement.
We present a case of 65-year-old female patient who presented with diplopia, dysphagia, and muscle weakness who was diagnosed with myasthenia gravis.
She developed significant sinoatrial node block with prolonged asystole after starting treatment with pyridostigmine which was successfully treated with hyoscyamine, thus avoiding pacemaker placement.
American Psychological Association (APA)
Khan, Mohammad Saud& Tiwari, Abhinav& Khan, Zubair& Sharma, Himani& Taleb, Mohammad& Hammersley, Jeffrey. 2017. Pyridostigmine Induced Prolonged Asystole in a Patient with Myasthenia Gravis Successfully Treated with Hyoscyamine. Case Reports in Cardiology،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1144143
Modern Language Association (MLA)
Khan, Mohammad Saud…[et al.]. Pyridostigmine Induced Prolonged Asystole in a Patient with Myasthenia Gravis Successfully Treated with Hyoscyamine. Case Reports in Cardiology No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1144143
American Medical Association (AMA)
Khan, Mohammad Saud& Tiwari, Abhinav& Khan, Zubair& Sharma, Himani& Taleb, Mohammad& Hammersley, Jeffrey. Pyridostigmine Induced Prolonged Asystole in a Patient with Myasthenia Gravis Successfully Treated with Hyoscyamine. Case Reports in Cardiology. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1144143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144143