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Nephrotic Syndrome due to Focal Segmental Glomerulosclerosis Complicating Sjögren’s Syndrome: A Case Report and Literature Review
Joint Authors
Harada, Makoto
Ichikawa, Tohru
Kobayashi, Mamoru
Kurihara, Shigekazu
Ehara, Takashi
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Renal tubular acidosis and tubulointerstitial nephritis constitute the primary renal complications associated with Sjögren’s syndrome (SjS), and glomerulonephritis and nephrotic syndrome are rare.
Case Presentation.
A 79-year-old Japanese woman presented with bilateral leg edema and weight gain and was diagnosed with nephrotic syndrome.
In addition, she reported a 5-year history of dryness of mouth and was diagnosed with SjS.
Renal biopsy revealed segmental glomerulosclerosis, with some specimens showing collapse of the glomerular capillary loops, proliferation of glomerular epithelial cells, and sclerotic lesions at the tubular poles, without spike formation, double contour lesions, or any other changes of the glomerular basement membrane.
Immunofluorescence staining showed no immune complex (immunoglobulin IgG, IgA, or IgM) or complement (C3) deposition in the glomerular capillary walls.
Based on these findings, she was diagnosed with focal segmental glomerulosclerosis (FSGS).
The administration of steroid and cyclosporine achieved complete remission of nephrotic syndrome.
Conclusion.
Although glomerular diseases are rare, a variety of glomerular lesions including FSGS are reported in patients with SjS.
Therefore, renal biopsy is warranted in patients with SjS presenting with severe urinary abnormalities.
American Psychological Association (APA)
Kurihara, Shigekazu& Harada, Makoto& Ichikawa, Tohru& Ehara, Takashi& Kobayashi, Mamoru. 2019. Nephrotic Syndrome due to Focal Segmental Glomerulosclerosis Complicating Sjögren’s Syndrome: A Case Report and Literature Review. Case Reports in Rheumatology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1144187
Modern Language Association (MLA)
Kurihara, Shigekazu…[et al.]. Nephrotic Syndrome due to Focal Segmental Glomerulosclerosis Complicating Sjögren’s Syndrome: A Case Report and Literature Review. Case Reports in Rheumatology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1144187
American Medical Association (AMA)
Kurihara, Shigekazu& Harada, Makoto& Ichikawa, Tohru& Ehara, Takashi& Kobayashi, Mamoru. Nephrotic Syndrome due to Focal Segmental Glomerulosclerosis Complicating Sjögren’s Syndrome: A Case Report and Literature Review. Case Reports in Rheumatology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1144187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144187