Chronic Myeloid Leukemia in a Patient Receiving Tofacitinib: A Case Report and Literature Review
Joint Authors
Medawar, Georgio
Chahrouri, Joseph
Said, Rabih
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Tofacitinib is a new oral Janus kinase inhibitor that has shown promising clinical benefit in various rheumatologic diseases.
However, many concerns related to the development of malignancies have been reported with its use.
Case Presentation.
A 43-year-old female patient received tofacitinib for refractory rheumatoid arthritis (RA).
Two years after 5 mg bid daily dosing, the patient developed chronic myelogenous leukemia (CML), for which she received imatinib and tofacitinib was discontinued.
She then remained in remission for rheumatoid arthritis and within the expected milestone outcome for her CML.
Conclusion.
This is the first reported case of CML after the use of tofacitinib.
This event is of particular interest knowing the possible benefits tofacitinib carries in the treatment of CML demonstrated in a few studies.
American Psychological Association (APA)
Medawar, Georgio& Chahrouri, Joseph& Said, Rabih. 2019. Chronic Myeloid Leukemia in a Patient Receiving Tofacitinib: A Case Report and Literature Review. Case Reports in Rheumatology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1144203
Modern Language Association (MLA)
Medawar, Georgio…[et al.]. Chronic Myeloid Leukemia in a Patient Receiving Tofacitinib: A Case Report and Literature Review. Case Reports in Rheumatology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1144203
American Medical Association (AMA)
Medawar, Georgio& Chahrouri, Joseph& Said, Rabih. Chronic Myeloid Leukemia in a Patient Receiving Tofacitinib: A Case Report and Literature Review. Case Reports in Rheumatology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1144203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144203