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Hepatic Iron Overload following Liver Transplantation from a C282YH63D Compound Heterozygous Donor
Joint Authors
Veitsman, E.
Pras, E.
Pappo, O.
Arish, A.
Eshkenazi, R.
Feray, C.
Calderaro, J.
Azoulay, D.
Ari, Z. Ben
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-31
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Hereditary hemochromatosis (HH) is a genetic disease associated with progressive iron overload, eventually leading in some cases to damage of parenchymal organs, such as the liver, pancreas, and heart.
Although the gene had been identified (HFE), HH pathogenesis remains to be fully elucidated.
We report here, for the first time, a case of inadvertent transplantation of a liver from a donor with C282Y/H63D compound heterozygosity into a nonhemochromatotic 19-year-old Caucasian male recipient with primary sclerosing cholangitis.
Progressive iron overload occurred over 1.5 years, as observed in liver biopsies and iron studies, after ruling out secondary causes of iron overload.
This case strengthens the hypothesis that the liver, rather than the small intestine, plays a primary role in the maintenance of iron homeostasis.
American Psychological Association (APA)
Veitsman, E.& Pras, E.& Pappo, O.& Arish, A.& Eshkenazi, R.& Feray, C.…[et al.]. 2018. Hepatic Iron Overload following Liver Transplantation from a C282YH63D Compound Heterozygous Donor. Case Reports in Hepatology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1144208
Modern Language Association (MLA)
Veitsman, E.…[et al.]. Hepatic Iron Overload following Liver Transplantation from a C282YH63D Compound Heterozygous Donor. Case Reports in Hepatology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1144208
American Medical Association (AMA)
Veitsman, E.& Pras, E.& Pappo, O.& Arish, A.& Eshkenazi, R.& Feray, C.…[et al.]. Hepatic Iron Overload following Liver Transplantation from a C282YH63D Compound Heterozygous Donor. Case Reports in Hepatology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1144208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144208