A Case of Severe Symptomatic Central Nervous System Sarcoidosis Secondary to Treatment with Adalimumab
Joint Authors
Nnodum, Benedicta Nneoma
Dudley, Lauren
Hariri, Lida P.
Mavrommati, Despoina
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Antitumor necrosis factor-α therapy has been used effectively in treatment of many inflammatory diseases such as rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and inflammatory bowel disease.
There are increasing number of paradoxical reactions associated with this therapy that are being reported.
We present the case of a 63-year-old male with psoriatic arthritis maintained on adalimumab and methotrexate (previous treatment trials of prednisone and leflunomide) who developed severe symptomatic sarcoidosis in the brain, liver, and lung.
Upon discontinuation of adalimumab, the symptoms resolved but the imaging findings persisted.
Although the development of sarcoidosis (usually in the lung, skin, and eyes) while on antitumor necrosis factor-α therapy is increasingly reported, the brain and liver are less commonly involved but should be borne in mind by physicians when extensive granulomatous lesions develop.
American Psychological Association (APA)
Nnodum, Benedicta Nneoma& Hariri, Lida P.& Mavrommati, Despoina& Dudley, Lauren. 2019. A Case of Severe Symptomatic Central Nervous System Sarcoidosis Secondary to Treatment with Adalimumab. Case Reports in Rheumatology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1144276
Modern Language Association (MLA)
Nnodum, Benedicta Nneoma…[et al.]. A Case of Severe Symptomatic Central Nervous System Sarcoidosis Secondary to Treatment with Adalimumab. Case Reports in Rheumatology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1144276
American Medical Association (AMA)
Nnodum, Benedicta Nneoma& Hariri, Lida P.& Mavrommati, Despoina& Dudley, Lauren. A Case of Severe Symptomatic Central Nervous System Sarcoidosis Secondary to Treatment with Adalimumab. Case Reports in Rheumatology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1144276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144276