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Postinfantile Giant Cell Hepatitis with Features of Acute Severe Autoimmune Hepatitis Probably Triggered by Diclofenac in a Patient with Primary Myelofibrosis
Joint Authors
Dalekos, Georgios N.
Arvaniti, Pinelopi
Koukoulis, George K.
Zachou, Kalliopi
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Giant cell hepatitis (GCH) is commonly reported in neonatal and infantile liver diseases but rarely in adults where the term postinfantile GCH (PIGCH) is used.
PIGCH is associated with many diseases, including drugs toxicity, viruses, and autoimmune liver diseases, with autoimmune hepatitis (AIH) being the most prevalent.
We present a case of PIGCH in a 76-year-old female without known history of liver disease who suffered from an acute severe episode of hepatitis.
After careful exclusion of other hepatitis causes by imaging, virological, immunological, and microbiological investigations, a diagnosis of acute severe AIH (AS-AIH) was established.
The patient was started on corticosteroids but she did not respond and died 3 days later because of advanced acute liver failure.
Postmortem liver biopsy showed typical PIGCH lesions.
Physicians must keep this catastrophic entity in mind in cases of unexplained acute liver injury as, contrary to our case, prompt rescue therapy with corticosteroids may be life-saving.
American Psychological Association (APA)
Arvaniti, Pinelopi& Zachou, Kalliopi& Koukoulis, George K.& Dalekos, Georgios N.. 2018. Postinfantile Giant Cell Hepatitis with Features of Acute Severe Autoimmune Hepatitis Probably Triggered by Diclofenac in a Patient with Primary Myelofibrosis. Case Reports in Hepatology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1144278
Modern Language Association (MLA)
Arvaniti, Pinelopi…[et al.]. Postinfantile Giant Cell Hepatitis with Features of Acute Severe Autoimmune Hepatitis Probably Triggered by Diclofenac in a Patient with Primary Myelofibrosis. Case Reports in Hepatology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1144278
American Medical Association (AMA)
Arvaniti, Pinelopi& Zachou, Kalliopi& Koukoulis, George K.& Dalekos, Georgios N.. Postinfantile Giant Cell Hepatitis with Features of Acute Severe Autoimmune Hepatitis Probably Triggered by Diclofenac in a Patient with Primary Myelofibrosis. Case Reports in Hepatology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1144278
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144278