In Vitro Fertilization Using Luteinizing Hormone-Releasing Hormone Injections Resulted in Healthy Triplets without Increased Attack Rates in a Hereditary Angioedema Case
Joint Authors
Mete Gokmen, Nihal
Tunakan Dalgıç, Ceyda
Düşünür Günsen, Fatma
Bulut, Gökten
Sin, Aytül Zerrin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-13
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) is a rare, autosomal dominant disorder.
The management of pregnant patients with C1-INH-HAE is a challenge for the physician.
Intravenous plasma-derived nanofiltered C1-INH (pdC1INH) is the only recommended option throughout pregnancy, postpartum, and breastfeeding period.
In order to increase pregnancy rates, physicians use fertilization therapies increasing endogen levels of estrogens.
Therefore, these techniques can provoke an increase in the number and severity of edema attacks in C1-INH-HAE.
Our patient is a 32-year-old female, diagnosed with C1-INH-HAE type 1 since 2004.
She had been taking danazol 50–200 mg/day for 9 years.
Due to her pregnancy plans in 2013, danazol was discontinued.
PdC1INH was prescribed regularly for prophylactic purpose.
Triplet pregnancy occurred by in vitro fertilization using luteinizing hormone-releasing hormone (LHRH) injections.
In our patient, LHRH injections were done four times without causing any severe attack during in vitro fertilization.
Angioedema did not worsen during pregnancy and delivery due to the prophylactic use of intravenous pdC1INH in our patient.
According to the attack frequency and severity, there was no difference between the three pregnancy trimesters.
To our knowledge, this is the first published case of C1-INH-HAE receiving in vitro fertilization therapies without any angioedema attacks during pregnancy and delivery and eventually having healthy triplets with the prophylactic use of intravenous pdC1INH.
American Psychological Association (APA)
Tunakan Dalgıç, Ceyda& Düşünür Günsen, Fatma& Bulut, Gökten& Mete Gokmen, Nihal& Sin, Aytül Zerrin. 2018. In Vitro Fertilization Using Luteinizing Hormone-Releasing Hormone Injections Resulted in Healthy Triplets without Increased Attack Rates in a Hereditary Angioedema Case. Case Reports in Immunology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1144295
Modern Language Association (MLA)
Tunakan Dalgıç, Ceyda…[et al.]. In Vitro Fertilization Using Luteinizing Hormone-Releasing Hormone Injections Resulted in Healthy Triplets without Increased Attack Rates in a Hereditary Angioedema Case. Case Reports in Immunology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1144295
American Medical Association (AMA)
Tunakan Dalgıç, Ceyda& Düşünür Günsen, Fatma& Bulut, Gökten& Mete Gokmen, Nihal& Sin, Aytül Zerrin. In Vitro Fertilization Using Luteinizing Hormone-Releasing Hormone Injections Resulted in Healthy Triplets without Increased Attack Rates in a Hereditary Angioedema Case. Case Reports in Immunology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1144295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144295