A Case Report of Takayasu’s Arteritis and Ulcerative Colitis in a Pediatric Patient with Chronic Recurrent Multifocal Osteomyelitis Successfully Treated with Infliximab: Diagnostic Clues in Disease Associations and Immune Dysregulation
Joint Authors
De Guerra, Viveka Clare
Hashmi, Humaira
Kramer, Bree
Balluz, Rula
Son, Mary Beth
Stein, Deborah
Lieberman, Alicia
Zahra, Mahmoud
Abdul-Aziz, Rabheh
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Takayasu’s arteritis with comorbid chronic recurrent multifocal osteomyelitis and ulcerative colitis is rare in the pediatric population.
Treatment with anti-TNF alpha agents such as infliximab has been a successful treatment strategy in adults and can be used effectively in the pediatric population.
Case Presentation.
We present the case of a 15-year-old Caucasian girl with a history of chronic recurrent multifocal osteomyelitis and ulcerative colitis presenting with hypertensive emergency secondary to Takayasu’s arteritis with middle aortic syndrome.
She was treated with corticosteroids and methotrexate and ultimately required infliximab infusions of 15 mg/kg every 4 weeks to successfully control her symptoms and normalize her inflammatory markers.
Conclusions.
In this case, we discuss the use of infliximab in an adolescent patient with chronic recurrent multifocal osteomyelitis, ulcerative colitis, and Takayasu’s arteritis.
The significance of this case is determined by the unique occurrence of all three conditions in a pediatric patient, the important consideration of vasculitis in the differential of a pediatric patient presenting with hypertensive emergency, the need for vigilance for detecting diagnostic clues, signs, and symptoms, knowledge of disease associations when evaluating a patient with a predisposition for autoinflammatory conditions, and the use of increasing doses of infliximab to control symptoms.
American Psychological Association (APA)
De Guerra, Viveka Clare& Hashmi, Humaira& Kramer, Bree& Balluz, Rula& Son, Mary Beth& Stein, Deborah…[et al.]. 2019. A Case Report of Takayasu’s Arteritis and Ulcerative Colitis in a Pediatric Patient with Chronic Recurrent Multifocal Osteomyelitis Successfully Treated with Infliximab: Diagnostic Clues in Disease Associations and Immune Dysregulation. Case Reports in Rheumatology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1144296
Modern Language Association (MLA)
De Guerra, Viveka Clare…[et al.]. A Case Report of Takayasu’s Arteritis and Ulcerative Colitis in a Pediatric Patient with Chronic Recurrent Multifocal Osteomyelitis Successfully Treated with Infliximab: Diagnostic Clues in Disease Associations and Immune Dysregulation. Case Reports in Rheumatology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1144296
American Medical Association (AMA)
De Guerra, Viveka Clare& Hashmi, Humaira& Kramer, Bree& Balluz, Rula& Son, Mary Beth& Stein, Deborah…[et al.]. A Case Report of Takayasu’s Arteritis and Ulcerative Colitis in a Pediatric Patient with Chronic Recurrent Multifocal Osteomyelitis Successfully Treated with Infliximab: Diagnostic Clues in Disease Associations and Immune Dysregulation. Case Reports in Rheumatology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1144296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144296