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Effective Immunotherapy in Bone Marrow Metastatic Melanoma Presenting with Disseminated Intravascular Coagulopathy
Joint Authors
Gbadamosi, Bolanle
Ezekwudo, Daniel
Nayak, Bhadresh
Yu, Zhou
Gjorgova-Gjeorgjievski, Sandra
Xie, Ming
Robert, Colvin
Jaiyesimi, Ishmael
Huben, Marianne
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Malignant melanoma is responsible for the majority of skin cancer deaths and is increasing in prevalence.
Bone marrow (BM) involvement by melanoma is rare in the absence of widespread visceral disease.
Here, we report the case of a 30-year-old female who presented to the hospital with back pain, low-grade fever, and easy bruising.
She was found to be bicytopenic and in disseminated intravascular coagulopathy (DIC).
Surprisingly, BM biopsy showed extensive involvement by metastatic malignant melanoma in the absence of visceral or brain metastasis.
The unique presentation of this case and the challenge of management of a potentially treatable cancer in a critically ill patient are discussed, alongside a review of published cases of metastatic melanoma in the BM and an exploration of currently available treatment options.
The excellent response of our patient to combined immune checkpoint inhibitors has yet to be paralleled in the available literature.
American Psychological Association (APA)
Gbadamosi, Bolanle& Ezekwudo, Daniel& Nayak, Bhadresh& Yu, Zhou& Gjorgova-Gjeorgjievski, Sandra& Xie, Ming…[et al.]. 2018. Effective Immunotherapy in Bone Marrow Metastatic Melanoma Presenting with Disseminated Intravascular Coagulopathy. Case Reports in Immunology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1144318
Modern Language Association (MLA)
Gbadamosi, Bolanle…[et al.]. Effective Immunotherapy in Bone Marrow Metastatic Melanoma Presenting with Disseminated Intravascular Coagulopathy. Case Reports in Immunology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1144318
American Medical Association (AMA)
Gbadamosi, Bolanle& Ezekwudo, Daniel& Nayak, Bhadresh& Yu, Zhou& Gjorgova-Gjeorgjievski, Sandra& Xie, Ming…[et al.]. Effective Immunotherapy in Bone Marrow Metastatic Melanoma Presenting with Disseminated Intravascular Coagulopathy. Case Reports in Immunology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1144318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144318