Dynamics of a Virological Model for Cancer Therapy with Innate Immune Response

Abstract EN

The aim of this work is to present a virological model for cancer therapy that includes the innate immune response and saturation effect.

The presented model combines both the evolution of a logistic growing tumor and time delay which stands for the period of the viral lytic cycle.

We use the delay differential equation in order to model this time which also means the time needed for the infected tumor cells to produce new virions after viral entry.

We show that the delayed model has four equilibria which are the desired outcome therapy equilibrium, the complete failure therapy equilibrium, the partial success therapy free-immune equilibrium when the innate immune response has not been established, and the partial success therapy equilibrium with immune response.

Furthermore, the stability analysis of equilibria and the Hopf bifurcation are properly exhibited.