Immunosuppression with Antitumour Necrosis Factor Therapy Leading to Strongyloides Hyperinfection Syndrome
Joint Authors
Khaliq, Muhammad Farhan
Ihle, Rayan E.
Perry, James
Source
Case Reports in Infectious Diseases
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Strongyloides stercoralis is an endemic parasitic infection that can remain asymptomatic for years, but it can cause death in immunosuppressed individuals.
Here, we present a case of Strongyloides hyperinfection in a 75-year-old male secondary to sepsis and chronic immunosuppression due to TNF-α inhibitors.
Despite aggressive treatment including broad-spectrum antibiotics and antihelminths, his respiratory failure worsened and he died after palliative extubation.
S.
stercoralis infection remains a diagnostic challenge.
Presentation with Strongyloides is often nonspecific, and eosinophilia is absent in hyperinfection.
Diagnosis can be delayed, especially in low-prevalence areas where suspicion is low.
Strongyloides should be considered in the differential diagnosis in the presence of risk factors including immunosuppressive therapy, and a travel history should be carefully obtained.
Patients with recurrent enterobacterial sepsis or respiratory failure with diffuse infiltrates in the setting of eosinophilia should undergo testing for Strongyloides.
A multidisciplinary approach can result in earlier diagnosis and favorable outcomes.
American Psychological Association (APA)
Khaliq, Muhammad Farhan& Ihle, Rayan E.& Perry, James. 2018. Immunosuppression with Antitumour Necrosis Factor Therapy Leading to Strongyloides Hyperinfection Syndrome. Case Reports in Infectious Diseases،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1144600
Modern Language Association (MLA)
Khaliq, Muhammad Farhan…[et al.]. Immunosuppression with Antitumour Necrosis Factor Therapy Leading to Strongyloides Hyperinfection Syndrome. Case Reports in Infectious Diseases No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1144600
American Medical Association (AMA)
Khaliq, Muhammad Farhan& Ihle, Rayan E.& Perry, James. Immunosuppression with Antitumour Necrosis Factor Therapy Leading to Strongyloides Hyperinfection Syndrome. Case Reports in Infectious Diseases. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1144600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144600