An Unusual Case of CMVEBV Ventriculoencephalitis with Evolution to Primary Central Nervous System Lymphoma in HIV-Positive Patient
Joint Authors
Pereira, Aida
Borges, Gisela
Neves, Diana
Maury, Inês Pintado
Silva, Maria de Jesus
Source
Case Reports in Infectious Diseases
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-17
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Epstein–Barr virus (EBV) is a well-known cause of different types of malignancies particularly Burkitt’s lymphoma, nasopharyngeal carcinoma, Hodgkin’s lymphomas, and non-Hodgkin’s lymphomas including primary central nervous system lymphoma (PCNSL).
A higher tendency of malignant transformation associated with EBV has been noticed in immunocompromised patients, such as human immunodeficiency virus (HIV) infected patients.
The rapid and effective immune reconstitution is crucial to prevent PCNSL in HIV-positive patients.
We present a clinical case of a young patient diagnosed with HIV infection and medicated with antiretroviral therapy (ART) with poor immunological recovery.
After two weeks, he developed ventriculoencephalitis, observed in the cranial magnetic resonance imaging (MRI), caused by cytomegalovirus (CMV) and EBV, both with high serum viral load, rapidly evolving to PCNSL.
With this unusual clinical case, the authors want to draw attention to the importance of rapid immunological reconstitution in preventing the progression of EBV infection to PCNSL, as well as encouraging the confirmation of the usefulness of early combination of chemotherapy and antiviral therapy, in order to reach a more effective treatment of this herpesvirus infection and associated malignancies.
American Psychological Association (APA)
Borges, Gisela& Neves, Diana& Maury, Inês Pintado& Pereira, Aida& Silva, Maria de Jesus. 2018. An Unusual Case of CMVEBV Ventriculoencephalitis with Evolution to Primary Central Nervous System Lymphoma in HIV-Positive Patient. Case Reports in Infectious Diseases،Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1144650
Modern Language Association (MLA)
Borges, Gisela…[et al.]. An Unusual Case of CMVEBV Ventriculoencephalitis with Evolution to Primary Central Nervous System Lymphoma in HIV-Positive Patient. Case Reports in Infectious Diseases No. 2018 (2018), pp.1-3.
https://search.emarefa.net/detail/BIM-1144650
American Medical Association (AMA)
Borges, Gisela& Neves, Diana& Maury, Inês Pintado& Pereira, Aida& Silva, Maria de Jesus. An Unusual Case of CMVEBV Ventriculoencephalitis with Evolution to Primary Central Nervous System Lymphoma in HIV-Positive Patient. Case Reports in Infectious Diseases. 2018. Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1144650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144650