Relapsing Malaria: A Case Report of Primaquine Resistance
Joint Authors
Dijanic, Christopher
Nickerson, Jillian
Shakya, Sunita
Dijanic, Amanda
Fabbri, Marilyn
Source
Case Reports in Infectious Diseases
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-11
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Primaquine (an 8-aminoquinoline malarial therapy) is the only FDA-approved therapy to treat the hypnozoite stage of P.
vivax.
We think of relapse occurring because of parasitic resistance or poor compliance secondary to drug toxicities.
However, in patients with repeated treatment failure, we must consider CYP-450 mutations affecting drug metabolism as an important cause of relapse.
A 47-year-old man who travelled to a jungle in Venezuela was diagnosed with P.
falciparum and P.
vivax in July 2015.
He was treated with seven rounds of primaquine-based therapy in the following year, all resulted in relapse without further exposure to endemic areas.
On his eighth presentation, he was found to have CYP-4502D6 mutation that affected the metabolism and activation of primaquine.
Thereafter, he was treated without relapse.
Primaquine efficacy depends on many factors.
Understanding the mechanism responsible for malaria relapse is paramount for successful treatment and reduction in morbidity and mortality.
This case illustrates the importance of considering cytochrome mutations that affect drug efficacy in cases of relapsing malaria.
American Psychological Association (APA)
Dijanic, Christopher& Nickerson, Jillian& Shakya, Sunita& Dijanic, Amanda& Fabbri, Marilyn. 2018. Relapsing Malaria: A Case Report of Primaquine Resistance. Case Reports in Infectious Diseases،Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1144708
Modern Language Association (MLA)
Dijanic, Christopher…[et al.]. Relapsing Malaria: A Case Report of Primaquine Resistance. Case Reports in Infectious Diseases No. 2018 (2018), pp.1-3.
https://search.emarefa.net/detail/BIM-1144708
American Medical Association (AMA)
Dijanic, Christopher& Nickerson, Jillian& Shakya, Sunita& Dijanic, Amanda& Fabbri, Marilyn. Relapsing Malaria: A Case Report of Primaquine Resistance. Case Reports in Infectious Diseases. 2018. Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1144708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144708