Isolated Knee Arthritis as Early and Only Symptom of Whipple’s Disease

Joint Authors

Candrian, Christian
Giunchi, Dario
Marcoli, Natalie
Deabate, Luca
Delcogliano, Marco
Testa, Enrique
Gaffurini, Paolo

Source

Case Reports in Medicine

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-05-27

Country of Publication

Egypt

No. of Pages

4

Main Subjects

Medicine

Abstract EN

We report a case of isolated Whipple’s disease involving the knee of a 64-year-old female patient who presented recurrent monoarthritis whose origin was not clear.

Initially, the cause of the gradually invalidating symptoms was related to a meniscal lesion and a diffuse minor grade chondropathy, but pain and functional impairment suggested that more exams were needed.

Biopsies were performed during arthroscopy.

The histology showed highly inflammatory infiltrates with PAS staining negative for Tropheryma while PCR revealed the infection with Tropheryma whipplei.

This, following the recommendation of a rheumatologist and infectious disease specialist, led to biopsies of the gastrointestinal tract and analysis of the cerebrospinal fluid that showed no other organ involvement.

This confirms the scientific literature that an isolated monoarthritis without involvement of the gastrointestinal tract caused by this bacterium is rare but can occur as an early manifestation of potentially fatal systemic disease.

Moreover, a review of the scientific literature showed the uncertainty about epidemiology of this rare disease, suggesting that more and specific data are required.

American Psychological Association (APA)

Giunchi, Dario& Marcoli, Natalie& Deabate, Luca& Delcogliano, Marco& Testa, Enrique& Candrian, Christian…[et al.]. 2018. Isolated Knee Arthritis as Early and Only Symptom of Whipple’s Disease. Case Reports in Medicine،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1144847

Modern Language Association (MLA)

Giunchi, Dario…[et al.]. Isolated Knee Arthritis as Early and Only Symptom of Whipple’s Disease. Case Reports in Medicine No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1144847

American Medical Association (AMA)

Giunchi, Dario& Marcoli, Natalie& Deabate, Luca& Delcogliano, Marco& Testa, Enrique& Candrian, Christian…[et al.]. Isolated Knee Arthritis as Early and Only Symptom of Whipple’s Disease. Case Reports in Medicine. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1144847

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1144847