The Successful Treatment of a Case of Linear Psoriasis with Ixekizumab

Abstract EN

Linear psoriasis is an unusual clinical variation of psoriasis that manifests segmentally along the lines of Blaschko.

A major differential diagnosis is inflammatory linear verrucous epidermal nevus (ILVEN).

The treatment of linear psoriasis is often challenging, with inadequate response to biological agents reported in the literature.

We report a case of a 25-year-old African-American female who presented with asymptomatic hyperkeratotic papules along the lines of Blaschko and was subsequently diagnosed with linear psoriasis.

After failing conventional treatment regimens, the patient received a trial of ixekizumab with complete resolution of cutaneous lesions reported after 4 months and only 8 doses of the anti-IL-17 biologic agent.