A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis
Joint Authors
Jha, Pinky
Stromich, Jeremiah
Michalski, Basia
Swanson, Kurtis
Olasz, Edit
Source
Case Reports in Dermatological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Linear IgA bullous dermatosis (LABD) is an autoimmune vesiculobullous disease, which is typically idiopathic but can also rarely be caused by medications or infections.
Vancomycin is the most common drug associated with LABD.
Lesions typically appear 24 hours to 15 days after the first dose of vancomycin.
It is best characterized pathologically by subepidermal bulla (blister) formation with linear IgA deposition at the dermoepidermal junction.
Here we report an 86-year-old male with a history of left knee osteoarthritis who underwent a left knee arthroplasty and subsequently developed a prosthetic joint infection.
This infection was treated with intravenous vancomycin as well as placement of a vancomycin impregnated joint spacer.
Five days following initiation of antibiotic therapy, he presented with a vesiculobullous eruption on an erythematous base over his trunk, extremities, and oral mucosa.
The eruption resolved completely when intravenous vancomycin was discontinued and colchicine treatment was begun.
Curiously, complete resolution occurred despite the presence of the vancomycin containing joint spacer.
The diagnosis of vancomycin-induced linear IgA bullous dermatosis was made based on characteristic clinical and histopathologic presentations.
American Psychological Association (APA)
Jha, Pinky& Swanson, Kurtis& Stromich, Jeremiah& Michalski, Basia& Olasz, Edit. 2017. A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis. Case Reports in Dermatological Medicine،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1145004
Modern Language Association (MLA)
Jha, Pinky…[et al.]. A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis. Case Reports in Dermatological Medicine No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1145004
American Medical Association (AMA)
Jha, Pinky& Swanson, Kurtis& Stromich, Jeremiah& Michalski, Basia& Olasz, Edit. A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis. Case Reports in Dermatological Medicine. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1145004
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145004