Primary Gliosarcoma of the Cerebellum in a Young Pregnant Woman: Management Challenges and Immunohistochemical Features
Joint Authors
Syrmos, Nikolaos
Ganau, M.
Meloni, Marco
Serra, Salvatore
Bellisano, Giulia
Jeyaretna, Sanjeeva
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Gliosarcoma (GS) represents a rare, high-grade (WHO Grade IV), central nervous system neoplasm, characterized by a very poor prognosis.
Similar to other high-grade gliomas, GS affects mainly adults in the 5th-7th decade of life and presents a higher incidence in males.
The most reported locations of GS are the temporal lobe and the frontal lobe, while only eight cases of GS originating from the posterior cranial fossa are reported in the literature.
Case Description.
We report the first case occurring during pregnancy in a 33-year-old patient.
Diagnosis was obtained on the 15th week of gestation when patient presented with signs and symptoms of life-threatening raised intracranial pressure.
Surgical excision was followed by early recurrence and eventually disease progression because the patient refused adjuvant treatment to save her fetus.
Conclusions.
GS should be considered in the differential diagnosis of posterior cranial fossa tumors with radiological features of meningioma or glioblastoma, even in young patients.
To this regard, sarcomas, solitary fibrous tumors, and even metastases should be considered, especially in light of the tendency of GS to give rise to extracranial localizations.
Whenever an aggressive management with radical excision and adjuvant treatment is not safely achievable, disease progression is likely to be unavoidable.
American Psychological Association (APA)
Meloni, Marco& Serra, Salvatore& Bellisano, Giulia& Syrmos, Nikolaos& Jeyaretna, Sanjeeva& Ganau, M.. 2019. Primary Gliosarcoma of the Cerebellum in a Young Pregnant Woman: Management Challenges and Immunohistochemical Features. Case Reports in Surgery،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1145011
Modern Language Association (MLA)
Meloni, Marco…[et al.]. Primary Gliosarcoma of the Cerebellum in a Young Pregnant Woman: Management Challenges and Immunohistochemical Features. Case Reports in Surgery No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1145011
American Medical Association (AMA)
Meloni, Marco& Serra, Salvatore& Bellisano, Giulia& Syrmos, Nikolaos& Jeyaretna, Sanjeeva& Ganau, M.. Primary Gliosarcoma of the Cerebellum in a Young Pregnant Woman: Management Challenges and Immunohistochemical Features. Case Reports in Surgery. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1145011
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145011