Development of Asymmetric Facial Depigmentation in a Patient Treated with Dasatinib with New-Onset Hypovitaminosis D: Case Report and Review of the Literature
Joint Authors
Tung, Rebecca
Swan, James
Webb, Kirsten C.
Harasimowicz, Magdalena
Janeczek, Monica
Speiser, Jodi
Source
Case Reports in Dermatological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Dasatinib is a second-generation tyrosine kinase inhibitor (TKI) used to treat imatinib-resistant chronic myelogenous leukemia (CML), as well as other Philadelphia chromosome-positive lymphoproliferative disorders.
While the most commonly reported cutaneous side effects with this therapy include a morbilliform eruption, skin exfoliation, and skin irritation, pigmentary abnormalities have also been observed, albeit much more rarely.
We present the case of a 72-year-old South Asian male with CML who presented with new-onset hypopigmentation of his face and scalp three years after a dose increase of dasatinib therapy, in the setting of newly discovered borderline hypovitaminosis D.
Dasatinib and the other TKIs are believed to induce dyschromias via modulation of the c-kit receptor and its associated signaling pathway, which is involved in melanocyte survival, proliferation, and migration.
American Psychological Association (APA)
Webb, Kirsten C.& Harasimowicz, Magdalena& Janeczek, Monica& Speiser, Jodi& Swan, James& Tung, Rebecca. 2017. Development of Asymmetric Facial Depigmentation in a Patient Treated with Dasatinib with New-Onset Hypovitaminosis D: Case Report and Review of the Literature. Case Reports in Dermatological Medicine،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1145023
Modern Language Association (MLA)
Webb, Kirsten C.…[et al.]. Development of Asymmetric Facial Depigmentation in a Patient Treated with Dasatinib with New-Onset Hypovitaminosis D: Case Report and Review of the Literature. Case Reports in Dermatological Medicine No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1145023
American Medical Association (AMA)
Webb, Kirsten C.& Harasimowicz, Magdalena& Janeczek, Monica& Speiser, Jodi& Swan, James& Tung, Rebecca. Development of Asymmetric Facial Depigmentation in a Patient Treated with Dasatinib with New-Onset Hypovitaminosis D: Case Report and Review of the Literature. Case Reports in Dermatological Medicine. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1145023
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145023